Near field scanning optical microscopy : volumetry in biomedical publications since 2000

This chart was built by searching PubMed for publications mentionning near field scanning optical microscopy.

Atomic Force Microscopy : volumetry in biomedical publications since 2000

This chart was built by searching PubMed for publications mentionning atomic force microscopy.

Atomic force microscopy detects differences in the surface brush of normal and cancerous cells

Using an atomic force microscope (AFM), researchers at Clarkson University in New York have found that normal cells have “brushes” of one length on their surface while cancerous cells have two brush lengths that have very different densities to the brushes on normal cells. Cancer and normal cells may therefore interact very differently with nanoparticles ; according Igor Sokolov, one of the authors of the study, “this phenomenon could be used for cancer detection and potential treatment through drug delivery“. (article, abstract)

Early detection of aging cartilage and osteoarthritis using atomic force microscopy

According to a recent article (abstract) published in Nature Nanotechnology, illustrated and commented on MIT’s (article) :

 “(…) indentation-type atomic force microscopy (…) can monitor early damage in the cartilage of osteoarthritic patients undergoing hip or knee replacements (…). Changes due to aging and osteoarthritis are clearly depicted at the nanometre scale well before morphological changes can be observed using current diagnostic methods. Indentation-type atomic force microscopy may potentially be developed into a minimally invasive arthroscopic tool to diagnose the early onset of osteoarthritis in situ.” 

Such an “arthroscope”  would also be useful for assessing the effectiveness of osteoarthritis therapies currently under development. 

Nanoscale greetings

It’s here, thanks to Park Systems.

Cypher AFM

Asylum Research launches a new small sample AFM/SPM called Cypher; its main features are summed up on this page. The new AFM will also be presented later this month (November 20-21) at the AFM Forum at University College Dublin (Ireland).

Atomic Force Microscopy

One of the important and famous tools in nanotechnology is the Atomic Force Microscope (AFM). The information is gathered by feeling the surface with a mechanical probe instead of looking at it as is more traditionnally done with optical microscopes. Explanations about the operation principle of an AFM can for example be found here. The range of applications in physics, chemistry and even life sciences is already large. Here (1, 2, 3) are examples of biology image galleries on the websites of some of the main AFM manufacturers.