Gold nanoparticles and magnetic microparticles to detect an indicator of prostate cancer


A new assay developped by US and Austrian researchers uses gold nanoparticles and DNA as amplification agents to detect prostate specific antigen (PSA), a protein associated with prostate cancer. The immunoassay is based on the use of 1) PSA antibody-functionalised gold nanoparticles decorated with DNA strand and 2) magnetic microparticles functionalised with a second PSA antibody. In solution, these two particles both bind to PSA ; the probes can then be magnetically separated thanks to the presence of the magnetic particles. DNA is then cleaved from the gold nanoparticles surface and its quantity (measured owing to a scanometric assay) indirectly indicates the level of PSA initially present in the sample. According to the researchers, this assay is ~300 times more sensitive than other commercial assays (see for example this article for more details).

[[[ Additional links suggested by Nanocolors :

# Gold nanoparticles in biomedical publications since 2000

# Functionalized nanoparticles in patents since 2000

# Gold nanoparticles for cancer detection animation ]]]

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: