New phase I clinical trial : antibacterial properties of silicon incorporated with quaternary ammonium polyethylenimine nanoparticles

The Hadassah Medical Organization plan to start in January 2010 a phase I clinical trial entitled “Antibacterial properties of silicon incorporated with quaternary ammonium polyethylenimine nanoparticles” now registered in the Clinicaltrials.gov database under reference NCT01007240. According to this page, “the aim of this study is to evaluate the antibacterial activity of crosslinked quaternary ammonium polyethylenimine (PEI) nanoparticles [...]

Gold nanoparticles and magnetic microparticles to detect an indicator of prostate cancer

A new assay developped by US and Austrian researchers uses gold nanoparticles and DNA as amplification agents to detect prostate specific antigen (PSA), a protein associated with prostate cancer. The immunoassay is based on the use of 1) PSA antibody-functionalised gold nanoparticles decorated with DNA strand and 2) magnetic microparticles functionalised with a second PSA [...]

Focus on medical/pharma-related nano trends

Medical and pharma applications of nanotech are one of the key editorial lines of Nanocolors blog ; here is a recap of the 10 medical/pharma-related trend charts already released, ranked by number of visits.
Nano patents & the top 10 big pharmaceutical companies
Nanoparticles in clinical trial phases
Nanoparticles in clinical trials since 2000
Nano & drug delivery [...]

New phase I clinical trial : BikDD nanoparticles in patients with advanced pancreatic cancer

The MD Anderson Cancer Center and the National Cancer Institute plan to start in May 2010 a phase I clinical trial involving a nanoparticle formulation, now registered in the Clinicaltrials.gov database under reference NCT00968604. According to this page, “the goal of this clinical research study is to find the highest tolerable dose of BikDD nanoparticle that [...]

A nanotech sensor to distinguish between the breath of lung cancer patients and healthy controls

Israeli researchers have demonstrated that an array of sensors based on functionalized gold nanoparticles in combination with pattern recognition methods can distinguish between the breath of lung cancer patients and healthy controls. Their study was published online in Nature Nanotechnology on August 30th in an article entitled “Diagnosing lung cancer in exhaled breath using gold [...]

Nanoparticles & cancer therapy : volumetry in biomedical publications since 2000

This chart was built by searching PubMed for publications mentionning nanoparticles and “cancer therapy” in their title or abstract.

Preclinical efficacy of calcium nanoparticles adjuvanted influenza vaccines including H1N1 and H5N1

According to a presentation entitled “BioVant Calcium Phosphate (CaP) Nanoparticles: An Effective Safe Adjuvant for Influenza Vaccines including H1N1 and H5N1” given by BioSante Pharmaceuticals at the Immunotherapeutics & Vaccine Summit (ImVacS) last week : ”BioSante’s vaccine adjuvant, BioVant™, increased the protective effect of vaccines for multiple flu strains, including a potential new vaccine against H1N1 [...]

Nano & vaccines : volumetry in patents since 2000

This chart was built by searching the Espacenet database for patents mentionning the prefixes “nano” and “vaccin” in their title or abstract.

Launch of topical pain relievers using nanotech for sustained delivery

Concept Laboratories is launching MyOmega, supposedly the first line of topical pain relievers using nanotechnology to produce timed-release pain relief. According to the company’s press release : “The secret behind MyOmega(R)’s extended release is a nanosphere-encapsulated cooling system. Each nanosphere within the IcePearls(TM) system has a designated release time. Some nanospheres are activated right away, [...]

EPA draft report : “Nanomaterial case studies : nanoscale titanium dioxide in water treatment and in topical sunscreen”

The EPA released this July for review and public comment a draft version of a (rather huge) report entitled “Nanomaterial case studies : nanoscale titanium dioxide in water treatment and in topical sunscreen” (222 p).
According to the preamble (p 14) : ” (…) This document is a starting point to determine what is known and what [...]